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Discuss the factors that influence radiation response in cancers and
normal tissues

a) Define and explain the phenomena of
i) “potentially lethal damage repair” and
ii) “sublethal damage repair” in cells after irradiation.
(4
marks)
b) List the mechanisms by which a drug can sensitize tumour cells to
radiation.
(3
marks)
c) Define the terms “volume doubling time” and “potential volume
doubling time” in tumours. Explain the factors that influence the
difference in volume doubling time and potential volume doubling time
in tumours.
(3
marks)
Question 6
a) Discuss the factors that influence radiation response in cancers and
normal tissues.
(7
marks)
b) Discuss the role of normal tissue vasculature in the radiation response. (3
marks)


 

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