Discuss the factors that influence radiation response in cancers
and
normal tissues
a) Define and explain the phenomena of
i) “potentially lethal damage repair” and
ii) “sublethal damage repair” in cells after irradiation.
(4
marks)
b) List the mechanisms by which a drug can sensitize tumour
cells to
radiation.
(3
marks)
c) Define the terms “volume doubling time” and “potential
volume
doubling time” in tumours. Explain the factors that influence
the
difference in volume doubling time and potential volume
doubling time
in tumours.
(3
marks)
Question 6
a) Discuss the factors that influence radiation response in
cancers and
normal tissues.
(7
marks)
b) Discuss the role of normal tissue vasculature in the
radiation response. (3
marks)
. .
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